Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Yang C-H, Bergsma A, Drougard A, Dror E, PERMUTE, Chandler DP, Schramek D, Triche TJ Jr., Pospisilik JA. 2025. TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states. Nat Cancer.
Zhou W, Johnson BK, Morrison J, Beddows I, Eapen J, Katsman E, Semwal A, Habib W, Heo L, Laird PW, Berman B, Triche Jr TJ, Shen H. 2024. BISCUIT: an efficient, standards-compliant tool suite for simultaneous genetic and epigenetic inference in bulk and single-cell studies. Nuc Acids Res 52(6):e32.
Unterman I, Avrahami D, Katsman E, Triche Jr. TJ, Glaser B, Berman BP. 2024. CelFiE-ISH: a probabilistic model for multi-cell type deconvolution from single-molecule DNA methylation haplotypes. Genome Biol 25:151.
Nguyen N, Carpenter KA, Ensing J, Gilliland C, Rudisel EJ, Mu EM, Thurlow KE, Triche Jr. TJ, Grainger S. 2024. EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish. Sci Sig 17(832).
Abla O, Ries RE, Triche Jr TJ, Gerbing RB, Hirsch B, Raimondi S, Cooper TM, Farrar JE, Buteyn N, Harmon LM, Wen H, Deshpande AJ, Kolb EA, Gamis AS, Aplenc R, Alonzo T, Meshinchi S. 2024. Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia. Blood Adv.
Tucker DW, Pangal DJ, Du R, Gogia AS, Tafreshi A, Ruzevick J, Hurth KT, Triche Jr TJ, Micko A, Carpten JD, Shiroishi MS, Carmichael JD, Rhie SK, Zada G. 2023. Validation of Myc-associated protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma. PLoS One 18(4):e0284949.
Underwood A, Rasicci DT, Hinds D, Mitchell JT, Zieba JK, Mills J, Arnold NE, Cook TW, Moustaqil M, Gambin Y, Sierecki E, Fontaine F, Vanderweele S, Das AS, Cvammen W, Sirpilla O, Soehnlen X, Bricker K, Alokaili M, Green M, Heeringa S, Wilstermann AM, Freeland TM, Qutob D, Milsted A, Jauch R, Triche Jr. TJ, Krawczyk CM, Bupp CP, Rajasekaran S, Francois M, Prokop JW. 2023. Evolutionary landscape of SOX genes to inform genotype-to-phenotype relationships. Genes 14(1):222.
Bertrums EJM, Smith JL, Harmon L, Ries RE, Want YCJ, Alonzo TA, Menssen AJ, Chisholm KM, Leonti AR, Tarlock K, Ostronoff F, Pogosova-Agadjanyan EL, Kaspers GJL, Hasle H, Dworzak M, Walter C, Muhlegger N, Moreiro C, Pardo L, Hirsch B, Raimondi S, Cooper TM, Aplenc R, Gamis AS, Kolb EA, Farrar JE, Stirewalt D, Ma X, Shaw TI, Furlan SN, Eidenschink Brodersen L, Loken MR, van den Heuvel-Eibrink MM, Zwaan M, Triche Jr TJ, Goemans BF, Meshinchi S. 2023. Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia. Haematologica.
Farrar JE, Smith JL, Othus M, Huang BJ, Wang YC, Ries R, Hylkema T, Pogosova-Agadjanyan EL, Challa S, Leonti A, Shaw TI, Triche Jr TJ, Gamis AS, Aplenc R, Kolb EA, Ma X, Stirewalt DL, Alonzo AT, Meshinchi S. 2023. Long noncoding RNA expression independently predicts outcome in pediatric acute myeloid leukemia. J Clin Oncol.
Dozmorov MG, Mu W, Davis ES, Lee S, Triche Jr TJ, Phanstiel DH, Love MI. 2022. CTCF: An R/bioconductor data package of human and mouse CTCF binding sites. Bioinform Adv 2(1):vbac097.
Huang BJ, Smith JL, Farrar JE, Wang Y-C, Umeda M, Ries RE, Leonti AR, Crowgey E, Furlan SN, Tarlock K, Armendariz M, Liu Y, Shaw TI, Wei L, Gerbing RB, Cooper TM, Gamis AS, Aplenc R, Kolb EA, Rubnitz J, Ma J, Klco JM, Ma X, Alonzo TA, Triche Jr TJ, Meshinichi S. 2022. Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia. Nat Commun 13(1):5487.
Lee BD, Gitter A, Greene CS, Raschka S, Maguire F, Titus AJ, Kessler MD, Lee AJ, Triche Jr TJ, Boca SM. 2022. Ten quick tips for deep learning in biology. PLoS Comput Biol 18(3):e1009803.
Neman J, Franklin M, Madaj Z, Deshpande K, Triche Jr TJ, Sadlik G, Carmichael JD, Chang E, Yu C, Strickland BA, Zada G. 2022. Use of predictive spatial modeling to reveal that primary cancers have distinct central nervous system topography patterns of brain metastasis. J Neurosurg 136(1):88–96.
Wilson SL, Shen SY, Harmon L, Burgener JM, Triche Jr T, Bratman SV, De Carvalho DD, Hoffman MM. 2022. Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls. Cell Rep Methods 2(9):100294.
Yang CH*, Fagnocchi L*, Apostle S, Wegert V, Casani-Galdón S, Landgraf K, Panzeri I, Dror E, Heyne S, Wörpel T, Chandler DP, Lu D, Yang T, Gibbons E, Guerreiro R, Brás J, Thomasen M, Grunnert LG, Vaag AA, Gillberg L, Grundberg, E, Conesa A, Körner A, PERMUTE, Pospisilik JA. 2022. Independent phenotypic plasticity axes define distinct obesity subtypes. Nat Metab.
*Co-first authorship
**Highlighted in News & Views
***Dr. Triche is part of PERMUTE
Bolouri H, Ries R, Pardo L, Hylkema T, Zhou W, Smith JL, Leonti A, Loken M, Farrar JE, Triche Jr TJ, Meshinchi S. 2021. A B-cell development gene regulatory network is activated in infant AML. PLOS One.
Neman J, Franklin M, Madaj Z, Deshpande K, Triche Jr TJ, Sadlik G, Carmichael JD, Chang E, Yu C, Strickland BA, Zada G. 2021. Use of predictive spatial modeling to reveal that primary cancers have distinct central nervous system topography patterns of brain metastasis . J Neurosurg.
Kaeding AJ, Barwe SP, Gopalakrishnapillai A, Ries RE, Alonzo TA, Gerbing RB, Correnti C, Loken MR, Eidenschink Broderson L, Pardo L, Le, QH, Tang T, Leonti AR, Smith JL, Chou CK, Xu M, Triche Jr. T, Kornblau SM, Kolb EA, Tarlock K, Meshinchi S. 2021. Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia. Blood Adv 5 (9): 2350–2361.
Chassé MH, Johnson BK, Boguslawski EA, Sorensen KM, Rosien JE, Kang MH, Reynolds CP, Heo L, Madaj ZB, Beddows I, Foxa GE, Kitchen-Goosen SM, Williams BO, Triche TJ Jr, Grohar PJ. 2021. Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor. EMBO Mol Med 13(2):e12640.
Grit JL, Johnson BK, Dischinger PS, Essenburg CJ, Adams M, Campbell S, Pollard K, Pratilas CA, Triche TJ Jr., Graveel CR, Steensma MR. 2021. Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling. Epi Chromatin 14(7).
Smith JL, Ries RE, Hylkema T, Alonzo TA, Gerbing RB, Santaguida MT, Eidenschink Brodersen L, Pardo L, Cummings CL, Loeb KR, Le Q, Imren S, Leonti AR, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche Jr TJ, Nguyen C, Meerzaman D, Loken MR, Oehler VG, Bolouri H, Meshinchi S. 2020. Comprehensive transcriptome profiling of cryptic CBFA2T3–GLIS2 fusion–positive AML defines novel therapeutic options: A COG and TARGET pediatric AML study. 2020. Clin Can Res.
George JW, Fan H, Johnson B, Carpenter TJ, Foy KK, Chatterjee A, Patterson AL, Koeman J, Adams M, Madaj ZB, Chesla D, Marsh EE, Triche TJ, Shen H, Teixeira JM. 2019. Integrated epigenome, exome, and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids. Cell Rep.
Triska P, Kaneva K, Merkurjev D, Sohail N, Falk MJ, Triche Jr. J, Biegel JA, Gai X. 2019. Landscape of germline and somatic mitochondrial DNA mutations in pediatric malignancies. Cancer Res.
Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche TJ, Salhia B, Carpten J, Llor X, Ellias NA. 2018. Lack of APC somatic mutation is associated with early onset colorectal cancer in African Americans. Carcinogenesis.
Sun W, Triche TJ, Malvar J, Gaynon P, Sposto R, Yang X, Bittencourt H, Place AE, Messinger Y, Fraser C, Dalla-Pozza L, Salhia B, Jones P, Wayne AS, Gore L, Cooper TM, Liang G. 2018. A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from TACL consortium. Blood 131(10):1145–1148.
Bolouri H*, Farrer JE*, Triche TJ*, Ries RH*, Lim EL, Alonzo TA, Ma Y, Moore R, Mungall AJ, Marra MA, Zhang J, Ma X, Liu Y, Liu Y, Guidry Auvil JM, Davidsen TM, Gesuwan P, Hermida LC, Salhia B, Capone S, Ramsingh G, Zwaan CM, Noort S, Piccolo SR, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S. 2017. The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med.
*Equal contributions
Colombo AR, Zubair A, Thiagarajan D, Nuzhdin S, Triche TJ, Ramsingh G. 2017. Suppression of transposable elements in leukemic stem cells. Sci Rep 7:7029.
The Cancer Genome Atlas Research Network. 2017. Integrated genomic and molecular characterization of cervical cancer. Nature 543:378–384.
*Triche TJ was one of 306 collaborators
Fortin JP, Triche TJ, Hansen KD. 2016. Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array. Bioinformatics 33(4):558–560.
Gopalakrishnan R, Matta H, Tolani B, Triche TJ, Chaudhary PM. 2016. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in PEL in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene 35(14):1797–1810.
The Cancer Genome Atlas Research Network. 2016. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164(3):550–563.
*Triche TJ was one of 162 collaborators
The Cancer Genome Atlas Research Network. 2015. Comprehensive, integrative genomic analysis of diffuse lower-grade glioma. N Eng J Med 371(26):2481–2498.
*Triche TJ was one of 328 collaborators
The Cancer Genome Atlas Research Network. 2015. Genomic classification of cutaneous melanoma. Cell 161(7):1681–1696.
*Triche TJ was one of 352 collaborators
The Cancer Genome Atlas Research Network. 2015. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517:576–582.
*Triche TJ was one of 348 collaborators
The Cancer Genome Atlas Research Network. 2014. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513(7517):202–209.
*Triche TJ was one of 315 collaborators
The Cancer Genome Atlas Research Network. 2014. The somatic genomic landscape of chromophobe renal cell carcinoma. Cell 26(3):319–330.
*Triche TJ was one of 225 collaborators
Perttula A, Pitkaäniemi J, Heinonen OP, Finkle WD, Triche TJ, Gergov M, Vuori E. 2014. Second-generation antihistamines exhibit a protective effect on drivers in traffic: A preliminary population-based case-control study. Traffic Inj Prev 15(6):551–555.
The Cancer Genome Atlas Research Network. 2014. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511(7511):543–550.
*Triche TJ was one of 383 collaborators
Lay FD, Triche TJ, Tsai YC, Su SF, Martin SE, Daneshmand S, Skinner EC, Liang G, Chihara Y, Jones PA. 2014. Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res 24(4):545–553.
The Cancer Genome Atlas Research Network. 2014. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507(7492):315–322.
*Triche TJ was one of 367 collaborators
Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche TJ, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Feedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso E, Chanock SJ, Laird-Offringa IA, Landi MT. 2014. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun 5:3365.
The Cancer Genome Atlas Research Network. 2013. The somatic genomic landscape of glioblastoma. Cell 155(2):462–477.
*Triche TJ was one of 242 collaborators
The Cancer Genome Atlas Research Network. 2013. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113–1120.
*Triche TJ was one of 346 collaborators
The Cancer Genome Atlas Research Network. 2013. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499(7456):43–49.
*Triche TJ was one of 346 collaborators
The Cancer Genome Atlas Research Network. 2013. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Eng J Med (368):2059–2074.
*Triche TJ was a primary author and one of 39 collaborators
The Cancer Genome Atlas Research Network. 2013. Integrated genomic characterization of endometrial carcinoma. Nature 497(7447):67–73.
*Triche TJ was one of 313 collaborators
Triche TJ, Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD. 2013. Low-level processing of Illumina Infinium DNA methylation beadarrays. Nuc Acid Res 41(7):e90.
The Cancer Genome Atlas Research Network. 2012. Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61–70.
*Triche TJ was one of 357 collaborators
The Cancer Genome Atlas Research Network. 2012. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330–337.
*Triche TJ was one of 326 collaborators
The Cancer Genome Atlas Research Network. 2012. Comprehensive genomic characterization of squamous cell lung cancers. Nature 498(7417):519–525.
*Triche TJ was one of 412 collaborators
The Cancer Genome Atlas Research Network. 2011. Integrated genomic analyses of ovarian carcinoma. Nature 474(7353):609–615.
*Triche TJ was one of 297 collaborators
Lewinger JP, Conti DV, Baurley JW, Triche TJ, Thomas DC. 2007. Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol 31(8):871–882.